Motif ID: HOX{A4,D4}.p2

Z-value: 1.167


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXD4chr2_+_1767243580.361.7e-01Click!
HOXA4chr7_-_27136876-0.146.1e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_26345294 1.431


chr5_-_43326922 1.413 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chrX_-_53646332 1.361 HUWE1
HECT, UBA and WWE domain containing 1
chr12_-_44919818 1.343 SLC38A1
solute carrier family 38, member 1
chr10_+_28918672 1.331 WAC
WW domain containing adaptor with coiled-coil
chr18_+_29573152 1.236 ASXL3
additional sex combs like 3 (Drosophila)
chr12_-_10464308 1.191 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr3_+_99484421 1.130 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr15_-_75259714 1.090 PEAK1
NKF3 kinase family member
chrX_+_144710557 1.076 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chr18_+_59295123 1.066 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr3_-_115380539 1.055 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr12_+_58369392 1.049 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr13_+_78068246 1.041 LOC780529
hypothetical LOC780529
chr4_+_70928718 1.036 NM_000200
HTN3
histatin 3
chr6_+_50894397 0.998 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr12_+_1596482 0.993 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr3_+_63859114 0.992 NM_001177387
ATXN7
ataxin 7
chr10_-_121592020 0.974 MCMBP
minichromosome maintenance complex binding protein
chr9_-_85773899 0.963 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr11_-_16380967 0.950 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr17_-_1195096 0.950 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chrX_-_111953009 0.946 NM_001113490
AMOT
angiomotin
chrX_+_99726445 0.898 NM_022144
TNMD
tenomodulin
chrX_+_114734074 0.875 NM_001136025
NM_001172335
PLS3

plastin 3

chrX_-_116991728 0.874 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr17_-_36165050 0.857 NM_181534
KRT25
keratin 25
chrX_+_109548940 0.848 NM_020769
RGAG1
retrotransposon gag domain containing 1
chr6_+_100161370 0.837 NM_021620
PRDM13
PR domain containing 13
chr12_-_10479810 0.831 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chrX_-_131401319 0.814 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr21_-_26175068 0.813 APP
amyloid beta (A4) precursor protein
chrX_-_15312390 0.808 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr3_-_69120188 0.805 C3orf64
chromosome 3 open reading frame 64
chrX_-_44945025 0.800 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr10_+_129237602 0.793 NM_001030013
NPS
neuropeptide S
chrX_-_104352005 0.782 NM_031274
TEX13A
testis expressed 13A
chr1_+_246432954 0.776 NM_001004689
OR2M3
olfactory receptor, family 2, subfamily M, member 3
chr5_+_140411144 0.767 NM_013340
PCDHB1
protocadherin beta 1
chrX_-_102661072 0.762 NM_080879
RAB40A
RAB40A, member RAS oncogene family
chr14_+_71065794 0.755 NM_015556
SIPA1L1
signal-induced proliferation-associated 1 like 1
chrX_+_37524190 0.748 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr7_-_122126422 0.747 NM_139175
RNF133
ring finger protein 133
chr4_+_53975597 0.744 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr19_+_14460757 0.738 NM_001146693
LOC100130932
small nuclear ribonucleoprotein G-like protein
chr9_-_21192201 0.735 NM_021057
IFNA7
interferon, alpha 7
chr12_+_29267863 0.733 NM_018099
FAR2
fatty acyl CoA reductase 2
chr11_+_33319680 0.723 HIPK3
homeodomain interacting protein kinase 3
chrX_+_37524250 0.715 CYBB
cytochrome b-245, beta polypeptide
chr3_+_99288706 0.705 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr3_-_47909001 0.683 MAP4
microtubule-associated protein 4
chr2_-_165259334 0.683 COBLL1
COBL-like 1
chr18_-_55136673 0.680 NM_181654
CPLX4
complexin 4
chr7_+_28418668 0.675 NM_182898
CREB5
cAMP responsive element binding protein 5
chr2_+_162189090 0.674 NM_001178015
NM_001178016
NM_022058
SLC4A10


solute carrier family 4, sodium bicarbonate transporter, member 10


chr3_+_99350859 0.673 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr3_-_18455207 0.661 NM_001131010
SATB1
SATB homeobox 1
chr7_+_20621769 0.661 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr9_-_21229975 0.657 NM_002172
IFNA14
interferon, alpha 14
chr14_+_95915774 0.655 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr11_+_35154775 0.651 CD44
CD44 molecule (Indian blood group)
chr11_-_7917642 0.648 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr17_+_51585834 0.645 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr7_-_132371208 0.639 EEF1G
eukaryotic translation elongation factor 1 gamma
chr1_-_51660328 0.637 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr1_-_156078115 0.635 NM_005894
CD5L
CD5 molecule-like
chr11_+_88550687 0.632 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr8_-_67253234 0.618 NM_000756
CRH
corticotropin releasing hormone
chr14_-_94677807 0.614 NM_030621
DICER1
dicer 1, ribonuclease type III
chrX_-_114374860 0.612 NM_020871
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr9_-_21340885 0.609 NM_021002
IFNA6
interferon, alpha 6
chrX_+_55951280 0.609


chr4_-_66218777 0.608 EPHA5
EPH receptor A5
chr7_+_18296569 0.602 HDAC9
histone deacetylase 9
chr16_+_74868676 0.596 NM_033401
CNTNAP4
contactin associated protein-like 4
chr11_-_62753574 0.586 NM_199352
SLC22A25
solute carrier family 22, member 25
chr4_-_75083160 0.580 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr4_+_70831387 0.578 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chrX_-_32083506 0.576 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr3_-_116348780 0.575 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr15_+_46200460 0.575 NM_205850
SLC24A5
solute carrier family 24, member 5
chr2_-_180135559 0.573 NM_001113398
ZNF385B
zinc finger protein 385B
chr1_-_167865973 0.572 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr12_-_10953427 0.568 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr1_+_158426908 0.567 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr7_-_81237162 0.567 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr5_-_146415782 0.566 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr1_-_152394215 0.559 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr10_+_118295417 0.558 NM_000936
PNLIP
pancreatic lipase
chr10_-_92671005 0.555 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_42934910 0.553 YBX1
Y box binding protein 1
chrX_-_123925343 0.553 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr1_-_100416358 0.548 NM_144620
LRRC39
leucine rich repeat containing 39
chr10_-_126706442 0.546 NM_022802
CTBP2
C-terminal binding protein 2
chrX_-_37916138 0.546 SRPX
sushi-repeat containing protein, X-linked
chr11_-_13474101 0.543 NM_000315
PTH
parathyroid hormone
chr9_+_108726257 0.541 ZNF462
zinc finger protein 462
chr4_+_71235259 0.536 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr6_-_133008834 0.536 NM_138327
TAAR1
trace amine associated receptor 1
chr6_+_154449334 0.534 NM_001145287
OPRM1
opioid receptor, mu 1
chr7_+_142590633 0.526 NM_176881
TAS2R39
taste receptor, type 2, member 39
chr15_-_41195994 0.525 RPS3A
ribosomal protein S3A
chr17_-_36181927 0.523 NM_181539
KRT26
keratin 26
chr18_+_59374372 0.519 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr6_+_55300225 0.518 NM_207410
GFRAL
GDNF family receptor alpha like
chrX_-_33267646 0.517 NM_000109
DMD
dystrophin
chr9_-_21132143 0.516 NM_002177
IFNW1
interferon, omega 1
chr17_-_46140015 0.515 NM_052855
ANKRD40
ankyrin repeat domain 40
chr5_-_95044415 0.514 NM_031952
SPATA9
spermatogenesis associated 9
chrX_+_92815667 0.511 NM_001171109
NM_001171110
NM_001171111
NM_173698
FAM133A



family with sequence similarity 133, member A



chr4_+_70896236 0.510 NM_001009181
NM_003154
STATH

statherin

chr7_+_94953148 0.500 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr15_+_49988882 0.499 TMOD3
tropomodulin 3 (ubiquitous)
chr5_+_152850276 0.499 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr8_-_102005697 0.498 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr10_-_35403173 0.494 NM_001198778
NM_001198779
CUL2

cullin 2

chr1_+_156701895 0.494 NM_001004473
OR10K1
olfactory receptor, family 10, subfamily K, member 1
chr8_-_72431274 0.492 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr14_-_59264044 0.491 NM_206857
RTN1
reticulon 1
chr12_-_54150188 0.490 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr5_+_170668892 0.485 NM_021025
TLX3
T-cell leukemia homeobox 3
chr10_-_37931864 0.483 NM_001190489
MTRNR2L7
MT-RNR2-like 7
chr5_+_140546839 0.482 NM_019119
PCDHB9
protocadherin beta 9
chr8_-_13416554 0.480 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr5_+_115415061 0.478 NM_001195581
LOC644100
hypothetical LOC644100
chrX_+_96025562 0.477 NM_013347
RPA4
replication protein A4, 30kDa
chr18_-_46046771 0.477 NM_145020
CCDC11
coiled-coil domain containing 11
chrX_-_119329334 0.472 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr13_-_96444604 0.468 NM_080818
OXGR1
oxoglutarate (alpha-ketoglutarate) receptor 1
chr3_-_109730858 0.467 NM_014981
MYH15
myosin, heavy chain 15
chr8_-_82522175 0.466 NM_002677
PMP2
peripheral myelin protein 2
chr19_+_9064854 0.464 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr14_+_89792646 0.464 NM_002802
PSMC1
proteasome (prosome, macropain) 26S subunit, ATPase, 1
chr13_-_69580459 0.463 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr8_-_120033240 0.462 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr9_+_96561750 0.461 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr15_-_41664335 0.458 NM_014659
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chrX_+_102727068 0.457 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr3_-_166278969 0.457 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr5_+_53787187 0.456 NM_006308
HSPB3
heat shock 27kDa protein 3
chr18_+_74957475 0.453


chr8_-_25338472 0.452 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chr15_-_23204887 0.452 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr22_+_29696662 0.452


chr4_+_70950747 0.449 NM_002159
HTN1
histatin 1
chr8_-_131483395 0.447 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr10_-_98311813 0.445 TM9SF3
transmembrane 9 superfamily member 3
chr4_-_44348414 0.445 NM_182592
YIPF7
Yip1 domain family, member 7
chr4_-_64957595 0.442 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr11_+_22644732 0.441 NM_001143830
GAS2
growth arrest-specific 2
chr11_+_55629094 0.438 NM_001005200
OR8H2
olfactory receptor, family 8, subfamily H, member 2
chr1_-_150328153 0.438 NM_001008536
TCHHL1
trichohyalin-like 1
chr12_-_7793335 0.437 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chrX_-_119329307 0.436 FAM70A
family with sequence similarity 70, member A
chr22_-_36305883 0.436 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chrX_+_99785818 0.432 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr3_-_155630197 0.432 NM_001038705
GPR149
G protein-coupled receptor 149
chrX_+_16578201 0.432 NM_004057
S100G
S100 calcium binding protein G
chr4_-_99283323 0.431 NM_174952
C4orf37
chromosome 4 open reading frame 37
chr7_-_83108682 0.427 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_+_182558795 0.421 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr9_+_102244005 0.419 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr15_+_46271158 0.418 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr11_-_128567302 0.415 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr4_+_151722526 0.415 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr7_-_121731721 0.407 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr10_-_69736600 0.407 PBLD
phenazine biosynthesis-like protein domain containing
chr11_-_104332631 0.402 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr10_+_91051685 0.402 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr12_+_84792203 0.401 NM_006183
NTS
neurotensin
chr17_-_61655915 0.401 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_+_93317374 0.400 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr5_-_16795336 0.400 MYO10
myosin X
chrX_-_77801480 0.399 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr11_+_68124400 0.398 PPP6R3
protein phosphatase 6, regulatory subunit 3
chr17_-_26648375 0.395 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr11_-_117628211 0.394 NM_198275
MPZL3
myelin protein zero-like 3
chrX_-_92815222 0.394 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chrX_-_111809929 0.392 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr10_-_116382089 0.391 ABLIM1
actin binding LIM protein 1
chr12_+_26017954 0.387 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr5_-_83052606 0.385 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr7_+_17349425 0.385 AHR
aryl hydrocarbon receptor
chrX_+_38096679 0.385 NM_000531
OTC
ornithine carbamoyltransferase
chr6_-_22410993 0.384 NM_001163558
PRL
prolactin
chr11_-_27450808 0.381 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr9_-_106401514 0.381 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr10_-_74863303 0.380 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chrX_-_76824726 0.380 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr12_-_54965996 0.380 CS
citrate synthase
chr6_-_128263868 0.376 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr6_-_116553918 0.375 NM_000493
COL10A1
collagen, type X, alpha 1
chr8_-_11891168 0.372 NM_001033019
DEFB134
defensin, beta 134
chr4_-_72868598 0.372 NM_000583
GC
group-specific component (vitamin D binding protein)
chr8_-_82536312 0.371 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr2_+_88148413 0.370 NM_198274
SMYD1
SET and MYND domain containing 1
chr7_+_115650240 0.369 NM_152829
TES
testis derived transcript (3 LIM domains)
chr6_-_52736231 0.369 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr10_+_124135574 0.368 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr5_+_88221013 0.367 RPS6
ribosomal protein S6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.11 2.69e-10 GO:0007606 sensory perception of chemical stimulus
2.10 6.49e-09 GO:0007608 sensory perception of smell
1.67 9.09e-07 GO:0007600 sensory perception
1.36 9.70e-04 GO:0003008 system process
1.40 1.48e-03 GO:0050877 neurological system process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.13 1.57e-09 GO:0004984 olfactory receptor activity
1.64 7.89e-07 GO:0004930 G-protein coupled receptor activity
1.48 4.31e-06 GO:0004888 transmembrane receptor activity
1.35 2.21e-04 GO:0004872 receptor activity
1.28 2.58e-03 GO:0004871 signal transducer activity
1.28 2.58e-03 GO:0060089 molecular transducer activity